芳香族炭化水素受容体核内輸送体

ARNT
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
識別子
記号	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
外部ID	OMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	150,876,708 bp
遺伝子の位置 (マウス)
染色体	3番染色体 (マウス)
終点	95,404,551 bp
RNA発現パターン
	; ; ; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• sequence-specific DNA binding; • DNA結合; • protein dimerization activity; • DNA-binding transcription factor activity; • transcription coactivator activity; • aryl hydrocarbon receptor binding; • 転写因子結合; • 血漿タンパク結合; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein homodimerization activity; • sequence-specific double-stranded DNA binding; • nuclear receptor activity;
細胞の構成要素	• 細胞質; • transcription regulator complex; • 核質; • RNA polymerase II transcription regulator complex; • 細胞核; • 核内構造体;
生物学的プロセス	• positive regulation of vascular endothelial growth factor receptor signaling pathway; • 細胞分化; • 低酸素症への反応; • regulation of transcription, DNA-templated; • positive regulation of endothelial cell proliferation; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • positive regulation of erythrocyte differentiation; • embryonic placenta development; • mRNA transcription by RNA polymerase II; • positive regulation of protein sumoylation; • transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • intracellular receptor signaling pathway; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of vascular endothelial growth factor production; • positive regulation of glycolytic process; • positive regulation of transcription by RNA polymerase II; • positive regulation of hormone biosynthetic process; • 生体異物の代謝プロセス;
	出典:Amigo / QuickGO
オルソログ
	405
	11863
	ENSG00000143437
	ENSMUSG00000015522
	P27540
	P53762
NM_001197325; NM_001286035; NM_001286036; NM_001668; NM_178426;
	NM_178427; NM_001350224; NM_001350225; NM_001350226
	NM_001037737; NM_009709
NP_001184254; NP_001272964; NP_001272965; NP_001659; NP_848514;
	NP_001337153; NP_001337154; NP_001337155
	NP_001032826; NP_033839
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

芳香族炭化水素受容体核内輸送体（ARNT: aryl hydrocarbon receptor nuclear translocator）は、リガンド結合型芳香族炭化水素受容体（AhR）と複合体を形成するタンパク質であり、AhRが受容体として機能するために必要である。また、低酸素誘導因子1（HIF1）のベータサブユニットとしても知られている。TEL-ARNT融合タンパク質の発現をもたらす遺伝子座のt(1; 12)(q21; p13)転座は、急性骨髄芽球性白血病と関連している。この遺伝子について、異なるアイソフォームをコードする3つのスプライスバリアントが報告されている。

AhRは、生体異物代謝に関与するいくつかの酵素の誘導に関与している。リガンドを含まない、細胞質ゾル型のAhRは、熱ショックタンパク質90（Hsp90）と複合体を形成する。ダイオキシンと多環芳香族炭化水素を含むリガンドの結合は、リガンド結合サブユニットの核への転座をもたらす^[5]。生体異物代謝に関与する酵素の誘導は、これら酵素の遺伝子のプロモーター内の生体異物応答エレメントへのリガンド結合型AhRの結合を介して発生する。

相互作用分子

ARNTは、以下の生体分子と相互作用する。

脚注

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. Dannenberg (5 November 2008). “Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation”. Cancer Prevention Research 1 (6): 485–493. doi:10.1158/1940-6207.CAPR-08-0149. PMC 2680610. PMID 19138996.
^ Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
^ Arunas Kazlauskas, Sara Sundström, Lorenz Poellinger, and Ingemar Pongratz (April 2001). “The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor”. Molecular and Cellular Biology 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.
^ M.C. Lindebro, L. Poellinger, M.L. Whitelaw (01 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.
^ M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (April 1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.
^ Yumi Yamaguchi, M. Tien Kuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.
^ Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, and Yoshiaki Fujii-Kuriyama (01 January 1999). “Identification of a novel mechanism of regulation of Ah (dioxin) receptor function”. Genes & Development 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096.
^ ^a ^b John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
^ ^a ^b ^c Susan L. Woods, Murray L. Whitelaw (22 March 2002). “Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors”. Journal of Biological Chemistry 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.
^ Timothy V Beischlag, Song Wang, David W Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E Nelson, Markus R Probst, Michael G Rosenfeld, Oliver Hankinson (15 June 2002). “Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Molecular and Cellular Biology 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
^ ^a ^b Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (14 February 1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.
^ Norihisa Ooe, Koichi Saito, Nobuyoshi Mikami, Iwao Nakatuka, Hideo Kaneko (15 January 2004). “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.
^ P Moffett, M Reece, J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

参考文献

Volker H. Haase (01 August 2006). “Hypoxia-inducible factors in the kidney”. American Journal of Physiology-Renal Physiology 291 (2): F271–81. doi:10.1152/ajprenal.00071.2006. PMC 4232221. PMID 16554418.
Herminio Reyes, Suzanne Reisz-Porszasz and Oliver Hankinson (22 May 1992). “Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.”. Science 256 (5060): 1193–5. Bibcode: 1992Sci...256.1193R. doi:10.1126/science.256.5060.1193. PMID 1317062.
E C Hoffman, H Reyes, F F Chu, F Sander, L H Conley, B A Brooks, O Hankinson (17 May 1991). “Cloning of a factor required for activity of the Ah (dioxin) receptor.”. Science 252 (5008): 954–8. Bibcode: 1991Sci...252..954H. doi:10.1126/science.1852076. PMID 1852076.
Yumi Yamaguchi, M. TienKuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.
G L Wang, B H Jiang, E A Rue, and G L Semenza (6 June 1995). “Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.”. PNAS 92 (12): 5510–4. Bibcode: 1995PNAS...92.5510W. doi:10.1073/pnas.92.12.5510. PMC 41725. PMID 7539918.
M. C. Lindebro, L. Poellinger, M. L. Whitelaw (17 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.
B. D. Abbott, M. R. Probst, G. H. Perdew (November 1994). “Immunohistochemical double-staining for Ah receptor and ARNT in human embryonic palatal shelves.”. Teratology 50 (5): 361–6. doi:10.1002/tera.1420500507. PMID 7716743.
Suzanne Porszasz-Reisz, Markus Probst, B.N. Fukunaga, Oliver Hankinson (1994). “Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT).”. Molecular and Cellular Biology 14 (9): 6075–86. doi:10.1128/mcb.14.9.6075. PMC 359134. PMID 8065341.
Kazuo Maruyama, Sumio Sugano (28 January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
B. Johnson, B. A. Brooks, C. Heinzmann, A. Diep, T. Mohandas, R. S. Sparkes, H. Reyes, E. Hoffman, E. Lange, A. Gatti, Y-R. Xia, A. J. Lusis, O. Hankinson (September 1993). “The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3.”. Genomics 17 (3): 592–8. doi:10.1006/geno.1993.1377. PMID 8244375.
M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.
Bing-Hua Jiang, Elizabeth Rue, Guang L. Wang, Rick Roe, Gregg L. Semenza (26 July 1996). “Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1.”. Journal of Biological Chemistry 271 (30): 17771–8. doi:10.1074/jbc.271.30.17771. PMID 8663540.
J C Rowlands, I J McEwan, J A Gustafsson (01 September 1996). “Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.”. Molecular Pharmacology 50 (3): 538–48. PMID 8794892.
M Ema, M Morita, S Ikawa, M Tanaka, Y Matsuda, O Gotoh, Y Saijoh, H Fujii, H Hamada, Y Kikuchi, Y Fujii-Kuriyama (October 1996). “Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis.”. Molecular and Cellular Biology 16 (10): 5865–75. doi:10.1128/MCB.16.10.5865. PMC 231588. PMID 8927054.
Hollie I. Swanson, Yang Jun-hua (6 December 1997). “Mapping the protein/DNA contact sites of the Ah receptor and Ah receptor nuclear translocator.”. Journal of Biological Chemistry 271 (49): 31657–65. doi:10.1074/jbc.271.49.31657. PMID 8940186.
Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein.”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.
John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo.”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.
Masatsugu Ema, Shinichiro Taya, Noboru Yokotani, Kazuhiro Sogawa, Youichi Matsuda, and Yoshiaki Fujii-Kuriyama (19 April 1997). “A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.”. PNAS 94 (9): 4273–8. doi:10.1073/pnas.94.9.4273. PMC 20712. PMID 9113979.
P Moffett, M Reece, and J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference.”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

外部リンク

Aryl Hydrocarbon Receptor Nuclear Translocator - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143437 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015522 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[HSP90-2009-5] Duncan Hughes, Joseph B. Guttenplan, Craig B. Marcus, Kotha Subbaramaiah and Andrew J. Dannenberg (5 November 2008). “Heat Shock Protein 90 Inhibitors Suppress Aryl Hydrocarbon Receptor-Mediated Activation of CYP1A1 and CYP1B1 Transcription and DNA Adduct Formation”. Cancer Prevention Research 1 (6): 485–493. doi:10.1158/1940-6207.CAPR-08-0149. PMC 2680610. PMID 19138996.

[pmid9111057-6] Lucy A. Carver, Christopher A. Bradfield (25 April 1997). “Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo”. Journal of Biological Chemistry 272 (17): 11452–6. doi:10.1074/jbc.272.17.11452. PMID 9111057.

[pmid11259606-7] Arunas Kazlauskas, Sara Sundström, Lorenz Poellinger, and Ingemar Pongratz (April 2001). “The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor”. Molecular and Cellular Biology 21 (7): 2594–607. doi:10.1128/MCB.21.7.2594-2607.2001. PMC 86890. PMID 11259606.

[pmid7628454-8] M.C. Lindebro, L. Poellinger, M.L. Whitelaw (01 July 1995). “Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex”. EMBO Journal 14 (14): 3528–39. doi:10.1002/j.1460-2075.1995.tb07359.x. PMC 394421. PMID 7628454.

[pmid8384309-9] M Whitelaw, I Pongratz, A Wilhelmsson, J A Gustafsson, L Poellinger (April 1993). “Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor”. Molecular and Cellular Biology 13 (4): 2504–14. doi:10.1128/MCB.13.4.2504. PMC 359572. PMID 8384309.

[pmid7488247-10] Yumi Yamaguchi, M. Tien Kuo (12 October 1995). “Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system”. Biochemical Pharmacology 50 (8): 1295–302. doi:10.1016/0006-2952(95)02016-6. PMID 7488247.

[pmid9887096-11] Junsei Mimura, Masatsugu Ema, Kazuhiro Sogawa, and Yoshiaki Fujii-Kuriyama (01 January 1999). “Identification of a novel mechanism of regulation of Ah (dioxin) receptor function”. Genes & Development 13 (1): 20–5. doi:10.1101/gad.13.1.20. PMC 316371. PMID 9887096.

[pmid9079689-12] John B. Hogenesch, William K. Chan, Victoria H. Jackiw, R. Clark Brown, Yi-Zhong Gu, Marilyn Pray-Grant, Gary H. Perdew, Christopher A. Bradfield (28 March 1997). “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway”. Journal of Biological Chemistry 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.

[pmid11782478-13] Susan L. Woods, Murray L. Whitelaw (22 March 2002). “Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors”. Journal of Biological Chemistry 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.

[pmid12024042-14] Timothy V Beischlag, Song Wang, David W Rose, Joseph Torchia, Suzanne Reisz-Porszasz, Khurshid Muhammad, Walter E Nelson, Markus R Probst, Michael G Rosenfeld, Oliver Hankinson (15 June 2002). “Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex”. Molecular and Cellular Biology 22 (12): 4319–33. doi:10.1128/mcb.22.12.4319-4333.2002. PMC 133867. PMID 12024042.

[pmid9020169-15] Markus R. Probst, Chen-Ming Fan, Marc Tessier-Lavigne, Oliver Hankinson (14 February 1997). “Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein”. Journal of Biological Chemistry 272 (7): 4451–7. doi:10.1074/jbc.272.7.4451. PMID 9020169.

[pmid14701734-16] Norihisa Ooe, Koichi Saito, Nobuyoshi Mikami, Iwao Nakatuka, Hideo Kaneko (15 January 2004). “Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression”. Molecular and Cellular Biology 24 (2): 608–16. doi:10.1128/mcb.24.2.608-616.2004. PMC 343817. PMID 14701734.

[pmid9271372-17] P Moffett, M Reece, J Pelletier (September 1997). “The murine Sim-2 gene product inhibits transcription by active repression and functional interference”. Molecular and Cellular Biology 17 (9): 4933–47. doi:10.1128/mcb.17.9.4933. PMC 232345. PMID 9271372.

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