プロテアーゼ活性化受容体4

F2RL3
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	2ZPK, 3QDZ
識別子
記号	F2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
外部ID	OMIM: 602779 MGI: 1298207 HomoloGene: 36148 GeneCards: F2RL3
遺伝子の位置 (ヒト)
染色体	19番染色体 (ヒト)
終点	16,892,606 bp
遺伝子の位置 (マウス)
染色体	8番染色体 (マウス)
終点	73,490,502 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• thrombin-activated receptor activity; • シグナルトランスデューサー活性; • Gタンパク質共役受容体活性;
細胞の構成要素	• integral component of membrane; • 細胞外領域; • integral component of plasma membrane; • 膜; • 細胞膜;
生物学的プロセス	• platelet activation; • 止血; • phospholipase C-activating G protein-coupled receptor signaling pathway; • thrombin-activated receptor signaling pathway; • positive regulation of release of sequestered calcium ion into cytosol; • platelet dense granule organization; • response to wounding; • シグナル伝達; • 凝固・線溶系; • positive regulation of Rho protein signal transduction; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • Gタンパク質共役受容体シグナル伝達経路;
	出典:Amigo / QuickGO
オルソログ
	9002
	14065
	ENSG00000127533
	ENSMUSG00000050147
	Q96RI0
	O88634
	NM_003950
	NM_007975
	NP_003941
	NP_032001
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

プロテアーゼ活性化受容体4（プロテアーゼかっせいかじゅようたい4、英: protease-activated receptor 4、略称: PAR4）は、ヒトではF2RL3遺伝子にコードされるタンパク質である。F2RL3（coagulation factor II receptor-like 3）、thrombin receptor-like 3という名称でも知られる^[5]。

機能[編集]

PAR4はGタンパク質と共役した7回膜貫通受容体ファミリーに属する。また、プロテアーゼ活性化受容体ファミリーのメンバーでもある。細胞外のN末端領域のタンパク質分解切断によって活性化され、切断によって新たに形成されたN末端がテザードリガンドとして機能して受容体を活性化する^[5]。

出典[編集]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127533 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050147 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ ^a ^b “Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3”. 2021年9月5日閲覧。

関連文献[編集]

“Protease-activated receptors in cardiovascular diseases.”. Circulation 114 (10): 1070–7. (2006). doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.
“Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. (1998). Bibcode: 1998PNAS...95.6642X. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465.
“A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. (1998). Bibcode: 1998Natur.394..690K. doi:10.1038/29325. PMID 9716134.
“Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. (1998). doi:10.1074/jbc.273.36.23290. PMID 9722561.
“Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. (1999). doi:10.1172/JCI6042. PMC 408153. PMID 10079109.
“Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.”. Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. (1999). Bibcode: 1999PNAS...9611189A. doi:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152.
“Cathepsin G activates protease-activated receptor-4 in human platelets.”. J. Biol. Chem. 275 (10): 6819–23. (2000). doi:10.1074/jbc.275.10.6819. PMID 10702240.
“PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. (2000). Bibcode: 2000Natur.404..609N. doi:10.1038/35007085. PMID 10766244.
“Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. (2002). doi:10.4049/jimmunol.167.11.6615. PMID 11714832.
“Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.”. J. Immunol. 168 (7): 3577–85. (2002). doi:10.4049/jimmunol.168.7.3577. PMID 11907122.
“PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.”. Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. (2002). doi:10.1161/01.ATV.0000014742.56572.25. PMID 12006403.
“Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.”. Thromb. Haemost. 87 (4): 722–7. (2003). doi:10.1055/s-0037-1613071. PMID 12008957.
“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Owen WG (2003). “PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.
“Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.”. J. Thromb. Haemost. 1 (4): 798–804. (2003). doi:10.1046/j.1538-7836.2003.00138.x. PMID 12871418.
“The role of PAR4 in thrombin-induced thromboxane production in human platelets.”. Thromb. Haemost. 90 (2): 299–308. (2004). doi:10.1160/TH03-02-0103. PMID 12888878.
“ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.”. Mol. Cell. Biol. 23 (17): 6174–86. (2003). doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
“Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.”. Biochem. J. 376 (Pt 3): 733–40. (2004). doi:10.1042/BJ20030954. PMC 1223816. PMID 13678420.
“Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.”. J. Thromb. Haemost. 1 (10): 2206–15. (2004). doi:10.1046/j.1538-7836.2003.00436.x. PMID 14521606.

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