リシニン

Ricinine
	IUPAC名 4-Methoxy-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
	別称 3-cyano-4-methoxy-N-methyl-2-pyridone
識別情報
CAS登録番号	524-40-3
PubChem	10666
ChemSpider	10216
UNII	130UFS7AE0
EC番号	208-359-7
KEGG	C01526
ChEBI	CHEBI:18043;
ChEMBL	CHEMBL1329957
3DMet	B00311
	SMILES Cn1ccc(c(c1=O)C#N)OC;
	InChI InChI=1S/C8H8N2O2/c1-10-4-3-7(12-2)6(5-9)8(10)11/h3-4H,1-2H3 Key: PETSAYFQSGAEQY-UHFFFAOYSA-N;
特性
化学式	C8H8N2O2
モル質量	164.16 g mol−1
融点	200 °C, 473 K, 392 °F
危険性
半数致死量 LD50	340 mg/kg
	特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。

リシニン(Ricinine)は、トウゴマ(Ricinus)に含まれる毒性アルカロイドである^[2]。リシン中毒のバイオマーカーになりうる^[3]^[4]。

殺虫剤としての効果を持つ^[5]。

出典

^ Worbs, Sylvia; Kohler, Kernt; Pauly, Diana; Avondet, Marc-Andre; Schaer, Martin; Dorner, Martin B.; Dorner, Brigitte G. (24 October 2011). “Ricinus communis Intoxications in Human and Veterinary Medicine-A Summary of Real Cases”. Toxins 3 (10): 1332-1372. doi:10.3390/toxins3101332. PMC 3210461. PMID 22069699.
^ Peng, Jing; Cai, Shuang; Wang, Lin; Zhao, Nan; Zhang, Ting-jian; Chen, Zai-xing; Meng, Fan-hao; Dzeja, Petras (11 March 2014). “A Metabonomic Analysis of Serum from Rats Treated with Ricinine Using Ultra Performance Liquid Chromatography Coupled with Mass Spectrometry”. PLoS ONE 9 (3): e90416. Bibcode: 2014PLoSO...990416P. doi:10.1371/journal.pone.0090416. PMC 3949718. PMID 24618672.
^ Hamelin, Elizabeth I.; Johnson, Rudolph C.; Osterloh, John D.; Howard, David J.; Thomas, Jerry D. (November 2012). “Evaluation of Ricinine, a Ricin Biomarker, from a Non-Lethal Castor Bean Ingestion”. Journal of Analytical Toxicology 36 (9): 660-662. doi:10.1093/jat/bks077. PMC 4561852. PMID 23014889.
^ Pittman, C. T.; Guido, J. M.; Hamelin, E. I.; Blake, T. A.; Johnson, R. C. (6 March 2013). “Analysis of a Ricin Biomarker, Ricinine, in 989 Individual Human Urine Samples”. Journal of Analytical Toxicology 37 (4): 237-240. doi:10.1093/jat/bkt010. PMC 4547525. PMID 23471955.
^ Wachira, Sabina; Omar, Sabar; Jacob, Julia; Wahome, Martin; Alborn, Hans T; Spring, David R; Masiga, Daniel K; Torto, Baldwyn (2014). “Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae”. Parasites & Vectors 7 (1): 312. doi:10.1186/1756-3305-7-312. PMC 4098926. PMID 24996560.

[1] Worbs, Sylvia; Kohler, Kernt; Pauly, Diana; Avondet, Marc-Andre; Schaer, Martin; Dorner, Martin B.; Dorner, Brigitte G. (24 October 2011). “Ricinus communis Intoxications in Human and Veterinary Medicine-A Summary of Real Cases”. Toxins 3 (10): 1332-1372. doi:10.3390/toxins3101332. PMC 3210461. PMID 22069699.

[2] Peng, Jing; Cai, Shuang; Wang, Lin; Zhao, Nan; Zhang, Ting-jian; Chen, Zai-xing; Meng, Fan-hao; Dzeja, Petras (11 March 2014). “A Metabonomic Analysis of Serum from Rats Treated with Ricinine Using Ultra Performance Liquid Chromatography Coupled with Mass Spectrometry”. PLoS ONE 9 (3): e90416. Bibcode: 2014PLoSO...990416P. doi:10.1371/journal.pone.0090416. PMC 3949718. PMID 24618672.

[3] Hamelin, Elizabeth I.; Johnson, Rudolph C.; Osterloh, John D.; Howard, David J.; Thomas, Jerry D. (November 2012). “Evaluation of Ricinine, a Ricin Biomarker, from a Non-Lethal Castor Bean Ingestion”. Journal of Analytical Toxicology 36 (9): 660-662. doi:10.1093/jat/bks077. PMC 4561852. PMID 23014889.

[4] Pittman, C. T.; Guido, J. M.; Hamelin, E. I.; Blake, T. A.; Johnson, R. C. (6 March 2013). “Analysis of a Ricin Biomarker, Ricinine, in 989 Individual Human Urine Samples”. Journal of Analytical Toxicology 37 (4): 237-240. doi:10.1093/jat/bkt010. PMC 4547525. PMID 23471955.

[5] Wachira, Sabina; Omar, Sabar; Jacob, Julia; Wahome, Martin; Alborn, Hans T; Spring, David R; Masiga, Daniel K; Torto, Baldwyn (2014). “Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae”. Parasites & Vectors 7 (1): 312. doi:10.1186/1756-3305-7-312. PMC 4098926. PMID 24996560.

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関連項目

出典