Template:PBB/7157

Tumor protein p53
	PDB rendering based on 1TUP: P53 complexed with DNA
PDBに登録されている構造
PDB	Ortholog search: PDBe, RCSB, PDBj
PDBのIDコード一覧
	1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1JSP, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2OCJ, 2PCX, 2QVQ, 2QXA, 2QXB, 2QXC, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ
識別記号
記号	TP53; LFS1; P53; TRP53
その他ID	OMIM: 191170 MGI（英語版）: 98834 HomoloGene（英語版）: 460 ChEMBL: 4096 GeneCards: TP53 Gene
遺伝子オントロジー
分子機能	• DNA strand annealing activity; • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • RNA polymerase II transcription factor binding; • protease binding; • p53 binding; • DNA binding; • chromatin binding; • damaged DNA binding; • sequence-specific DNA binding transcription factor activity; • copper ion binding; • protein binding; • ATP binding; • transcription factor binding; • zinc ion binding; • enzyme binding; • protein kinase binding; • ubiquitin protein ligase binding; • histone deacetylase regulator activity; • histone acetyltransferase binding; • identical protein binding; • transcription regulatory region DNA binding; • metal ion binding; • protein heterodimerization activity; • protein N-terminus binding; • chaperone binding; • protein phosphatase 2A binding; • MDM2 binding;
細胞の構成要素	• chromatin; • nuclear chromatin; • insoluble fraction; • nucleus; • nucleoplasm; • nucleoplasm; • replication fork; • transcription factor TFIID complex; • chromatin assembly complex; • nucleolus; • cytoplasm; • mitochondrion; • endoplasmic reticulum; • cytosol; • cytosol; • nuclear matrix; • nuclear body; • PML body; • protein complex;
生物学的プロセス	• protein import into nucleus, translocation; • cell cycle checkpoint; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of transcription from RNA polymerase II promoter; • DNA strand renaturation; • in utero embryonic development; • somitogenesis; • T cell proliferation involved in immune response; • B cell lineage commitment; • T cell lineage commitment; • base-excision repair; • nucleotide-excision repair; • double-strand break repair; • regulation of transcription, DNA-dependent; • protein complex assembly; • apoptotic process; • apoptotic process; • response to DNA damage stimulus; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • ER overload response; • cell cycle arrest; • cell cycle arrest; • Ras protein signal transduction; • multicellular organismal development; • gastrulation; • negative regulation of neuroblast proliferation; • central nervous system development; • cell aging; • blood coagulation; • protein localization; • negative regulation of DNA replication; • cell proliferation; • negative regulation of cell proliferation; • determination of adult lifespan; • induction of apoptosis by intracellular signals; • rRNA transcription; • response to salt stress; • embryo development ending in birth or egg hatching; • response to X-ray; • response to gamma radiation; • cell differentiation; • negative regulation of cell growth; • DNA damage response, signal transduction by p53 class mediator; • DNA damage response, signal transduction by p53 class mediator; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of histone deacetylation; • mitotic cell cycle G1/S transition DNA damage checkpoint; • positive regulation of protein oligomerization; • T cell differentiation in thymus; • cellular protein localization; • cellular response to UV; • multicellular organism growth; • cellular response to drug; • cellular response to glucose starvation; • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; • regulation of apoptotic process; • positive regulation of apoptotic process; • negative regulation of apoptotic process; • negative regulation of apoptotic process; • positive regulation of neuron apoptosis; • interspecies interaction between organisms; • negative regulation of transcription, DNA-dependent; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription from RNA polymerase II promoter; • response to antibiotic; • regulation of mitochondrial membrane permeability; • negative regulation of fibroblast proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of catalytic activity; • negative regulation of helicase activity; • protein tetramerization; • chromosome organization; • regulation of cell cycle; • positive regulation of thymocyte apoptosis; • positive regulation of cell cycle arrest; • cellular response to hypoxia; • cellular response to ionizing radiation; • signal transduction by p53 class mediator resulting in induction of apoptosis; • positive regulation of release of cytochrome c from mitochondria; • positive regulation of cell aging; • replicative senescence; • oxidative stress-induced premature senescence; • positive regulation of reactive oxygen species metabolic process; • positive regulation of intrinsic apoptotic signaling pathway;
	出典: Amigo / EGO
RNA発現パターン
	その他参照発現データ
オルソログ
	表; 話; 編; 歴;

^ Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994). “Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations”. Science 265 (5170): 346-355. doi:10.1126/science.8023157. PMID 8023157.

[1] Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994). “Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations”. Science 265 (5170): 346-355. doi:10.1126/science.8023157. PMID 8023157.

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