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アスペルギロペプシンI

出典: フリー百科事典『ウィキペディア(Wikipedia)』
アスペルギロペプシンI
識別子
EC番号 3.4.23.18
CAS登録番号 9025-49-4
データベース
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB構造 RCSB PDB PDBj PDBe PDBsum
検索
PMC articles
PubMed articles
NCBI proteins
テンプレートを表示

アスペルギロペプシンI(Aspergillopepsin I, EC 3.4.23.18)は、以下の化学反応を触媒する酵素である[1][2][3][4][5][6][7][8][9][10]

幅広い基質特異性タンパク質を加水分解する。一般にP1位及びP1'位に疎水性残基を持つものを選択するが、P1位にリシンを持つものも許容し、トリプシノーゲンを活性化する。レンネットは切断しない。

この酵素は、様々なコウジカビ(Aspergillus属)が持つ。

出典

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  1. ^ “The site of diazoacetyl inhibitor attachment to acid proteinase of Aspergillus awamori--an analog of penicillopepsin and pepsin”. Biochemical and Biophysical Research Communications 49 (4): 1075–81. (November 1972). doi:10.1016/0006-291x(72)90322-1. PMID 4565799. 
  2. ^ “Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability”. Archives of Biochemistry and Biophysics 157 (2): 561–72. (August 1973). doi:10.1016/0003-9861(73)90675-9. PMID 4581238. 
  3. ^ “Aspergillus oryzae acid proteinase. Purification and properties, and formation of pi-chymotrypsin”. The Biochemical Journal 147 (1): 45–53. (April 1975). doi:10.1042/bj1470045. PMC 1165373. PMID 239702. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1165373/. 
  4. ^ “The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus”. Journal of Biochemistry 80 (5): 975–81. (November 1976). doi:10.1093/oxfordjournals.jbchem.a131385. PMID 12156. 
  5. ^ “Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity”. Biochimica et Biophysica Acta (BBA) - Enzymology 485 (2): 406–16. (December 1977). doi:10.1016/0005-2744(77)90176-0. PMID 21699. 
  6. ^ “Aspergillopepsin F-A carboxylic proteinase from Aspergillus foetidus”. Bioorg. Khim. 5: 595–603. (1976). 
  7. ^ “Studies on the peptide bond specificity and the essential groups of an acid proteinase from Aspergillus fumigatus”. The Italian Journal of Biochemistry 30 (3): 207–16. (1981). PMID 7024192. 
  8. ^ “The primary structure of aspergillopepsin A, aspartic proteinase from Aspergillus awamori. IV. Amino acid sequence of the enzyme”. Bioorg. Khim. 12: 1030–1047. (1986). 
  9. ^ “Purification and characterization of carboxyl proteinase from Aspergillus kawachii”. Agric. Biol. Chem. 50 (4): 1029–1033. (1986). doi:10.1271/bbb1961.50.1029. 
  10. ^ “Comparative study on the specificities of several fungal aspartic and acidic proteinases towards the tetradecapeptide of a renin substrate”. Agric. Biol. Chem. 52 (3): 787–793. (1988). doi:10.1271/bbb1961.52.787. 

外部リンク

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