町田泰則

町田 泰則（まちだ やすのり、1948年 - ）は、日本の分子生物学者（植物を材料とする）。名古屋大学大学院理学研究科特任教授、名誉教授。

タバコやシロイヌナズナを用いて、植物の細胞分裂や細胞分化及び成長の仕組みを研究している。これらの業績により、2010年にアメリカ科学振興協会（AAAS）のフェローに選ばれた。また最近、植物細胞の分裂の最終段階である細胞板形成の分子機構に関する研究により、日本植物学会 学術賞（2013年）と日本植物生理学会賞（2015年）を授与された。

プロフィール

• 1948年 群馬県渋川市出身
• 1972年 千葉大学理学部生物学科卒業
• 1978年 名古屋大学大学院理学研究科博士課程満了（理学博士）：岡崎令治、恒子教授の下、DNAの不連続的複製機構の研究
• 1978年 日本学術振興会奨励研究員
• 1979年－1982年 ニューヨーク州立大学医学部博士研究員：大坪栄一教授の下、DNAトンランスポジションの分子機構の研究
• 1982年－1984年 農林水産省植物ウイルス研究所研究員：クラウンゴール腫瘍形成の分子機構の研究
• 1984年－1987年 名古屋大学理学部助手：クラウンゴール腫瘍形成の分子機構の研究
• 1987年－1989年 名古屋大学理学部助教授：植物細胞の分裂と分化の研究
• 1989年－1997年 名古屋大学理学部（大学院理学研究科）教授：植物細胞の分裂と分化の研究
• 1997年－1999年 京都大学大学院理学研究科　教授
• 1999年－2012年 名古屋大学大学院理学研究科　教授
• 2012年ー現在　　名古屋大学大学院理学研究科　特任教授、名誉教授　

研究論文業績

＜主な原著論文＞

・Machida, Y., Okazaki, T. and Okazaki, R.: Discontinuous Replication of Replicative Form DNA from Bacteriophage φX174. Proc. Natl. Acad. Sci. USA. 74, 2776-2779 (1977)

・Wada A., Tachibana H., Ueno S., Hushimi Y and Machida Y.: Melting Fine Structure of DNA Fragments of Known Sequence from φX174. Nature 269, 352-353 (1977)

・Machida Y., Machida C., Ohtsubo H. and Ohtsubo E.: Fractors Determining Recombination Frequency Mediated by an Insertion Sequence IS1. Proc. Natl. Acad. Sci. USA 79, 277-281 (1982)

・Machida Y., Machida C. and Ohtsubo E.: A novel type of transposon generated by insertion element IS102 present in a pSC101 derivative. Cell 30, 29-36 (1982)

・Machida C., Machida Y., Wang H.-C. R., Ishizaki K. and Ohtsubo E.: Repression of cointegration ability of insetion element IS1 by transcriptional readthrough from flanking regions. Cell 34, 135-142 (1983)

・Machida Y., Sakurai M., Kiyokawa S., Ubasawa A., Suzuki Y. and Ikeda J.-E: Nucleotide sequence of the IS element found in the T-DNA region of mutant Ti plasmid pTiA66 and distribution of its homologues in octopine Ti plasmid. Proc. Natl. Acad. Sci. USA 81, 7495-7499 (1984)

・Machida Y., Machida C. and Ohtsubo E.: The insertion element IS1 encodes two structural genes responsible for its transposition. J. Mol. Biol. 177, 229-245 (1984)

・Machida C., Machida Y. and Ohtsubo E.: Both inverted repeat sequences of the insertion element IS1 provide promorter function for RNA polymerase. J. Mol. Biol. 177, 247-265 (1984)

・Machida C. and Machida Y.: Base substitutions in transposable element IS1 cause DNA duplication of variable length at the target site for plasmid cointegration. EMBO J. 6, 1799-1803 (1987)

・Usami S., Takebe I. and Machida Y.: Novel factor inducing Agrobacterium tumefaciens vir gene expression is present in monocotyledonous plants. Proc. Natl. Acad. Sci. USA 85, 3748-3752 (1988)

・Machida C. and Machida Y.: Regulation of IS1 transposition by the insA gene product. J. Mol. Biol. 208, 567-574 (1989)

・Shimoda N., Toyoda-Yamamoto A., Nagamine J., Usami S., Katayama M., Sakagami Y. and Machida Y.: Control of expression of Agrobacterium vir genes by synergistic actions of phenolic signal molecules and monosaccharides. Proc. Natl. Acad. Sci. USA 87, 6684-6688 (1990)

・Shimoda N., Toyoda-Yamamoto A., Aoki S. and Machida Y.: Genetic Evidence for an Interaction between the VirA Sensor Protein and the ChvE Sugar-binding protein of Agrobacterium. J. Biol. Chem. 268, 26552-26558 (1993)

・Yoshioka Y., Matsumoto S., Kojima S., Ohshima K., Okada N. and Machida Y.: Molecular characterization of a short interspersed repetitive element (SINE) from tobacco that exhibits sequence homology to specific tRNAs. Proc. Natl. Acad. Sci. USA 90, 6562-6566 (1993)

・Banno H., Hirano K., Nakamura T., Irie K., Nomoto S., Matsumoto K. and Machida Y.: NPK1, a tobacco gene that encodes a protein with a domain homologous to yeast BCK1, STE11 and Byr2 protein kinases. Mol. Cell Biol. 13, 4745-4752 (1993)

・Muranaka T., Banno H. and Machida Y.: Characterization of Tobacco Protein Kinase NPK5, a Homolog of Saccharomyces cerevisiae SNF1 That Constitutively Activates Expression of the Glucose-Repressible SUC2 Gene for a Secreted Invertase of S. cerevisiae. Mol. Cell Biol. 14, 2958-2965 (1994)

・Usami, S., Banno, H., Ito, Y., Nishihama, R. and Machida, Y.: Cutting activates a 46-kilodalton protein kinase in plants. Proc. Natl. Acad. Sci. USA 92, 8660-8664 (1995)

・Machida, C., Onouchi, H., Koizumi, J., Hamada, S., Semiarti, E., Torikai, S. and Machida, Y.: Characterization of the transposition pattern of the Ac element in Arabidopsis thaliana using endonuclease I-SceI. Proc. Natl. Acad. Sci. USA 94, 8675-8680 (1997)

・Nishihama, R., Ishikawa, M., Araki, S., Soyano, T., Asada, T., and Machida,Y.: The NPK1 mitogen-activated kinase kinase kinase is a regulator of cell-plate formation in plant cytokinesis. Genes Dev. 15, 352-363 (2001)

・Semiarti, E., Ueno, Y., Tsukaya, H., Iwakawa, H., Machida, C., and Machida, Y.: The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana regulates formation of a symmetric lamina, establishment of venation and repression of meristem-related homeobox genes in leaves. Development 128, 1771-1783 (2001)

・Tanaka, H., Onouchi, H., Kondo, M., Hara-Nishimura, I., Nishimura, M., Machida, C., and Machida, Y.: A subtilisin-like serine protease is required for epidermal surface formation in Arabidopsis embryos and juvenile plants. Development 128, 4681-4689 (2001)

・Nishihama, R., Soyano, T., Ishikawa, M., Araki, S., Tanaka, H., Asada, T., Irie, K., Ito, M., Terada, M., Banno, H., Yamazaki, Y., and Machida, Y.: Expansion of the Cell Plate in Plant Cytokinesis Requires a Kinesin-Like Protein/MAPKKK Complex. Cell 109, 87-99 (2002). Cover

・Iwakawa, H., Ueno, Y., Semiarti, E., Onouchi, H., Kojima, S., Tsukaya, H., Hasebe, M., Soma, T., Ikezaki, M., Machida, C., and Machida, Y.: The ASYMMETRIC LEAVES2 gene of Arabidopsis thaliana, required for formation of a symmetric flat leaf lamina, encodes a member of a novel family of proteins characterized by cysteine repeats and a leucine zipper. Plant & Cell Physiol. 43, 467-478 (2002). Cover

・Soyano, T., Nishihama, R., Morikiyo, K., Ishikawa, M., and Machida, Y.: NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis. Genes Dev. 17, 1055-1067 (2003)

・Araki, S., Ito, M., Soyano, T., Nishihama, R., and Machida, Y.: Mitotic cyclins stimulate the activity of c-Myb-like factors for transactivation of G2/M phase-specific genes of tobacco. J. Biol. Chem. 279, 32979 - 32988 (2004)

・Sasabe, M., Soyano, T., Takahashi, Y., Sonobe, S., Igarashi, H., Itoh, TJ., Hidaka, M., and Machida, Y.: Phosphorylation of NtMAP65-1 by a MAP kinase down-regulates its activity of microtubule bundling and stimulates progression of cytokinesis of tobacco cells. Genes Dev. 20, 1004-1014 (2006)

・Tanaka, H., Watanabe, M., Sasabe, M., Hiroe, T., Tanaka, T., Tsukaya, T., Ikezaki, M., Machida, C., and Machida, Y.: Novel receptor-like kinase ALE2 controls shoot development by specifying epidermis in Arabidopsis. Development 134, 1643-1652 (2007)

・Ueno, Y., Ishikawa, T., Watanabe, K., Terakura, S., Iwakawa, H., Okada, K., Machida, C. and Machida, Y.: Histone deacetylases and ASYMMETRIC LEAVES2 are involved in the establishment of polarity in leaves of Arabidopsis. Plant Cell 19(2), 445-457 (2007)

・Terakura, S., Ueno, Y., Tagami, H., Kitakura, S., Machida, C., Wabiko, H., Aiba, H., Otten, L., Tsukagoshi, H., Nakamura, K., and Machida, Y.: An oncoprotein from the plant pathogen Agrobacterium has histone-chaperone-like activity. Plant Cell 19, 2855-2865 (2007)

・Kosetsu, K., Matsunaga, S., Nakagam, H., Colcombet, J., Sasabe, M., Soyano, T., Takahashi, T., Hirt, H., and Machida, Y.: The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana. Plant Cell 23, 3778-3790 (Nov. 23 on line) (2010)

・Sasabe, M., Boudolf, V., De Veylder, L., Inzé, D., Genschik, P, and Machida, Y.: Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants. Proc. Natl. Acad. Sci. USA 108 (43), 17844-17849 (2011) [Oct 17, Epub]

・Iwasaki M., Takahashi, H., Iwakawa, H., Nakagawa, A., Ishikawa, T., Tanaka, H., Matsumura, Y., Pekker, I., Eshed, Y., Vial-Pradel, S., Ito, T., Watanabe, Y., Ueno, Y., Fukazawa, H., Kojima, S., Machida,, Y., and Machida, C.: Dual regulation of ETTIN (ARF3) gene expression by AS1-AS2, which maintains the DNA methylation level, is involved in stabilization of leaf adaxial-abaxial partitioning in Arabidopsis. Development 140, 1958-1969 (2013) (selected as "IN THIS ISSUE") doi: 10.1242/dev.085365

・Sasabe M, Ishibashi N, Haruta T, Minami A, Kurihara D, Higashiyama T, Nishihama R, Ito M and Machida Y.: The carboxyl-terminal tail of the stalk of Arabidopsis NACK1/HINKEL kinesin is required for its localization to the cell plate formation site. J Plant Res. Mar;128(2):327-36 (2015). doi: 10.1007/s10265-014-0687-2.

＜最近の総説と著作＞

・Sasabe, M. and Machida, Y.: MAP65: a bridge linking a MAP kinase to microtubule turnover. Curr. Opin. Plant Biol. 9, 563-570 (2006)

・Sasabe, M. and Machida, Y.: Regulation of organization and function of microtubules by the mitogen-activated protein kinase cascade during plant cytokinesis. Cytoskeleton 69, 913-918 (2012)

・Sasabe, M. and Machida, Y.: Signaling pathway that controls plant cytokinesis. in Signalling Pathways in Plants: ed. by Yasunori Machida, Chentao Lin & Fuyuhiko Tamanoi, THE ENZYMES, vol. 35, Burlington: Academic Press, pp. 145-165 (2014), http://dx.doi.org/10.1016/B978-0-12-801922-1.00006-3

・Ishibashi, N. Kitakura S, Terakura S, Machida C and Machida, Y.: Protein encoded by oncogene 6b from Agrobacterium tumefaciens has reprogramming potential and histone chaperone-like activity. In Progress of creal genome engineering mediated by Agrobacterium tumefaciens: Frontiers in PLANT SCIENCE, 28 October (2014), vol. 5, Article 572, p1-7, doi: 10.3389/fpls.2014.00572

・町田泰則、岡田清孝、山本興太朗 監修：「高校生物解説書」講談社（2014）

・Ito M and Machida Y.: Reprogramming of plant cells induced by 6b oncoproteins from the plant pathogen Agrobacterium. J. Plant Res. May;128(3):423-35 (2015). doi: 10.1007/s10265-014-0694-3.

・Machida C, Nakagawa A, Kojima S, Takahashi H, and Machida Y.: The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis. WIREs Developmental Biology Jun 24 (2015). doi: 10.1002/wdev.196. [Epub ahead of print]

受賞歴など

・1987年 日本植物学会奨励賞

・2002-2007年　21世紀COEプログラム『システム生命科学:分子シグナル系の統合』拠点リーダー

・2010年 Fellow of the American Association for the Advancement of Science

・2012-2013年　日本植物生理学会 会長

・2013年 （公社）日本植物学会賞　学術賞

・2015年 （一社）日本植物生理学会賞

外部リンク

• 21世紀COEプログラム研究成果報告書