核内受容体コアクチベーター5

NCOA5
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1V95, 2J7Y, 4ZI1
識別子
記号	NCOA5, CIA, bA465L10.6, nuclear receptor coactivator 5
外部ID	OMIM: 616825 MGI: 2385165 HomoloGene: 32496 GeneCards: NCOA5
遺伝子の位置 (マウス)
染色体	2番染色体 (マウス)
終点	164,876,787 bp
遺伝子オントロジー
分子機能	• 血漿タンパク結合; • クロマチン結合; • RNA結合;
細胞の構成要素	• 細胞核; • actin cytoskeleton; • 細胞外空間;
生物学的プロセス	• negative regulation of insulin receptor signaling pathway; • regulation of transcription, DNA-templated; • glucose homeostasis; • transcription, DNA-templated;
	出典:Amigo / QuickGO
オルソログ
	57727
	228869
	ENSG00000124160
	ENSMUSG00000039804
	Q9HCD5,Q5JY17
	Q91W39
	NM_020967
	NM_144892
	NP_066018; NP_001335077; NP_001335078; NP_001335079; NP_001335080
	NP_659141
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

核内受容体コアクチベーター5（NCOA5: nuclear receptor coactivator 5）あるいはCAI（coactivator independent of AF-2 function）は、ヒトのNCOA5遺伝子によってコードされているタンパク質である^[4]^[5]。

機能[編集]

NCOA5は、エストロゲン受容体α及びβ並びにオーファン核内受容体 Rev-ErbAβの共制御因子である。このタンパク質は細胞核に局在し、コアクチベーターとコリプレッサーの両方の機能を持つと考えられている。上記の受容体における、他の共受容体との相互作用を調節することが知られているAF2ドメインとは、NCOA5を含む核内受容体との相互作用とは関連しない。この遺伝子より産まれた、選択的スプライシングによる2つの転写変異体が発見されている^[4]。

脚注[編集]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039804 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ ^a ^b “Entrez Gene: NCOA5 nuclear receptor coactivator 5”. アメリカ国立生物工学情報センター. 2021年8月14日閲覧。
^ Frédéric Sauvé, Linda D. B. McBroom, Josette Gallant, Anna N. Moraitis, Fernand Labrie, and Vincent Giguère (January 2001). “CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant”. Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.

参考文献[編集]

Jesper V. Olsen, Blagoy Blagoev, Florian Gnad, Boris Macek, Chanchal Kumar, Peter Mortensen, Matthias Mann (03 Nov 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
W. Andy Tao, Bernd Wollscheid, Robert O'Brien, Jimmy K. Eng, Xiao-jun Li, Bernd Bodenmiller, Julian D. Watts, Leroy Hood & Ruedi Aebersold (2005). “Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry”. Nature Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
Ralph Brandenberger, Henry Wei, Sally Zhang, Shirley Lei, Jaji Murage, Gregory J Fisk, Yan Li, Chunhui Xu, Rixun Fang, Karl Guegler, Mahendra S Rao, Ramumkar Mandalam, Jane Lebkowski, Lawrence W Stanton (16 May 2004). “Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation”. Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Chao Jiang, Mitsuhiro Ito, Valerie Piening, Kristy Bruck, Robert G Roeder, Hua Xiao (25 Jun 2004). “TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription”. Journal of Biological Chemistry 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
Robert L Strausberg, Elise A Feingold, Lynette H Grouse, Jeffery G Derge, Richard D Klausner, Francis S Collins, Lukas Wagner, Carolyn M Shenmen, Gregory D Schuler, Stephen F Altschul, Barry Zeeberg, Kenneth H Buetow, Carl F Schaefer, Narayan K Bhat, Ralph F Hopkins, Heather Jordan, Troy Moore, Steve I Max, Jun Wang, Florence Hsieh, Luda Diatchenko, Kate Marusina, Andrew A Farmer, Gerald M Rubin, Ling Hong, Mark Stapleton, M Bento Soares, Maria F Bonaldo, Tom L Casavant, Todd E Scheetz, Michael J Brownstein, Ted B Usdin, Shiraki Toshiyuki, Piero Carninci, Christa Prange, Sam S Raha, Naomi A Loquellano, Garrick J Peters, Rick D Abramson, Sara J Mullahy, Stephanie A Bosak, Paul J McEwan, Kevin J McKernan, Joel A Malek, Preethi H Gunaratne, Stephen Richards, Kim C Worley, Sarah Hale, Angela M Garcia, Laura J Gay, Stephen W Hulyk, Debbie K Villalon, Donna M Muzny, Erica J Sodergren, Xiuhua Lu, Richard A Gibbs, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez, Michelle Whiting, Anup Madan, Alice C Young, Yuriy Shevchenko, Gerard G Bouffard, Robert W Blakesley, Jeffrey W Touchman, Eric D Green, Mark C Dickson, Alex C Rodriguez, Jane Grimwood, Jeremy Schmutz, Richard M Myers, Yaron S N Butterfield, Martin I Krzywinski, Ursula Skalska, Duane E Smailus, Angelique Schnerch, Jacqueline E Schein, Steven J M Jones, Marco A Marra, Mammalian Gene Collection Program Team (24 Dec 2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. PNAS 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
P Deloukas, L H Matthews, J Ashurst, J Burton, J G Gilbert, M Jones, G Stavrides, J P Almeida, A K Babbage, C L Bagguley, J Bailey, K F Barlow, K N Bates, L M Beard, D M Beare, O P Beasley, C P Bird, S E Blakey, A M Bridgeman, A J Brown, D Buck, W Burrill, A P Butler, C Carder, N P Carter, J C Chapman, M Clamp, G Clark, L N Clark, S Y Clark, C M Clee, S Clegg, V E Cobley, R E Collier, R Connor, N R Corby, A Coulson, G J Coville, R Deadman, P Dhami, M Dunn, A G Ellington, J A Frankland, A Fraser, L French, P Garner, D V Grafham, C Griffiths, M N Griffiths, R Gwilliam, R E Hall, S Hammond, J L Harley, P D Heath, S Ho, J L Holden, P J Howden, E Huckle, A R Hunt, S E Hunt, K Jekosch, C M Johnson, D Johnson, M P Kay, A M Kimberley, A King, A Knights, G K Laird, S Lawlor, M H Lehvaslaiho, M Leversha, C Lloyd, D M Lloyd, J D Lovell, V L Marsh, S L Martin, L J McConnachie, K McLay, A A McMurray, S Milne, D Mistry, M J Moore, J C Mullikin, T Nickerson, K Oliver, A Parker, R Patel, T A Pearce, A I Peck, B J Phillimore, S R Prathalingam, R W Plumb, H Ramsay, C M Rice, M T Ross, C E Scott, H K Sehra, R Shownkeen, S Sims, C D Skuce, M L Smith, C Soderlund, C A Steward, J E Sulston, M Swann, N Sycamore, R Taylor, L Tee, D W Thomas, A Thorpe, A Tracey, A C Tromans, M Vaudin, M Wall, J M Wallis, S L Whitehead, P Whittaker, D L Willey, L Williams, S A Williams, L Wilming, P W Wray, T Hubbard, R M Durbin, D R Bentley, S Beck, J Rogers (20 Dec 2001). “The DNA sequence and comparative analysis of human chromosome 20”. Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Frédéric Sauvé, Linda D. B. McBroom, Josette Gallant, Anna N. Moraitis, Fernand Labrie, and Vincent Giguère (2001). “CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant”. Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.
Takahiro Nagase, Reiko Kikuno, Manabu Nakayama, Makoto Hirosawa, Osamu Ohara (2001). “Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Research 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

外部リンク[編集]

NCOA5 protein, human - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000039804 - Ensembl, May 2017

[2] Human PubMed Reference:

[3] Mouse PubMed Reference:

[entrez-4] “Entrez Gene: NCOA5 nuclear receptor coactivator 5”. アメリカ国立生物工学情報センター. 2021年8月14日閲覧。

[pmid11113208-5] Frédéric Sauvé, Linda D. B. McBroom, Josette Gallant, Anna N. Moraitis, Fernand Labrie, and Vincent Giguère (January 2001). “CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant”. Molecular and Cellular Biology 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.

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