HEATリピート

出典: フリー百科事典『ウィキペディア(Wikipedia)』
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ヒートリピート
PDB 1qgk EBI.jpg
インポーチンβとインポーチンα IBBドメインの複合体の構造[1]
識別子
略号 HEAT
Pfam PF03810
Pfam clan CL0020
InterPro IPR001494
SMART SM000913
PROSITE PS50166
SCOP 1QGK
SUPERFAMILY 1QGK
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HEATリピート(ひーとりぴーと:HEAT repeats)は、多くのタンパク質に見られるリピート配列(構造)のひとつ[2]。ひとつのユニットは、30-40アミノ酸残基からなり、2本の両親媒性ヘリックスが折り畳まれた構造をつくる。このユニットが数十回繰り返されると、弾力性に富むソレノイド状構造を形成する[3][4][5]

HEATリピートの名前の由来[編集]

HEATの名前は、このリピート配列を共有する代表的な4つのタンパク質の頭文字に由来する:Huntingtin (ハンチントン病の責任タンパク質), Elongation factor 3 (EF3)(タンパク質合成伸長因子), Protein phosphatase 2A (PP2A) A subunit(プロテインホスファターゼ2AのAサブユニット) , TOR1 (target of rapamycin)(シグナル伝達に関わるタンパク質キナーゼ[6]

様々なHEATタンパク質とその構造[編集]

HEATリピートタンパク質の代表例として知られているものには、核-細胞質間輸送因子インポーチンβ (karyopherin βとも呼ばれる) ファミリー[7]コンデンシンコヒーシンの制御サブユニット[8]、セパレース[9]ATM (Ataxia telangiectasia mutated) やATR (Ataxia telangiectasia and Rad3 related)を含むPIKKs (phosphatidylinositol 3-kinase-related protein kinases)[10][11]微小管結合タンパク質XMAP215/Dis1/TOG[12]とCLASP[13]などがある。このようにHEATリピートをもつタンパク質の細胞内機能は多彩である。

これまでに、構造が解かれているHEATリピートタンパク質には以下のものがある。

  • 転写制御
    • 基本転写因子TFIIDのTAF6サブユニット[26]
    • TBP制御因子Mot1(Modifier of transcription 1)[27]
    • 転写開始因子Rrn3[28]
  • その他
    • API5 (Apoptosis inhibitor 5)[55]
    • V型ATPaseのHサブユニット[56]
    • 全身性エリテマトーデスの免疫応答の自己抗原Ro[57]
    • 細胞質ポリアデニル複合体symplekin[58]
    • 癌抑制遺伝子Tsc1[59]
    • COP9シグナロソームのサブユニット7(CSN7)[60]
    • PI4キナーゼStt4複合体のサブユニットEFR3[61]
    • レンズ上皮由来増殖因子LEDGFのIBD (HIV-1 integrase binding domain)[62]

類似の構造をもつリピート配列[編集]

HEATリピートと類似の構造をもつリピート配列として、アルマジロリピート(Armadillo [ARM] repeat)[63]、やPUFリピート(Pumilio/fem-3 mRNA binding factor [PUF] repeat[64][65])がある。

引用文献[編集]

[ヘルプ]
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