ホスホグリセリン酸デヒドロゲナーゼ

出典: フリー百科事典『ウィキペディア(Wikipedia)』
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ホスホグリセリン酸デヒドロゲナーゼ
識別子
EC番号 1.1.1.95
CAS登録番号 9075-29-0
データベース
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB構造 RCSB PDB PDBe PDBsum

D-3-ホスホグリセリン酸デヒドロゲナーゼ(D-3-phosphoglycerate dehydrogenase)は、ヒトではPHGDH遺伝子にコードされている酵素である[1]

この酵素はNAD+補因子として、3-ホスホグリセリン酸3-ホスホノオキシピルビン酸へ、2-ヒドロキシグルタル酸2-オキソグルタル酸へ変換する酸化還元酵素である。

脚注[編集]

  1. ^ Entrez Gene: PHGDH phosphoglycerate dehydrogenase”. 2007年12月20日閲覧。

参考文献[編集]

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  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
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  • Pind S, Slominski E, Mauthe J, et al. (2002). “V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.”. J. Biol. Chem. 277 (9): 7136–43. doi:10.1074/jbc.M111419200. PMID 11751922. 
  • Klomp LW, de Koning TJ, Malingré HE, et al. (2001). “Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.”. Am. J. Hum. Genet. 67 (6): 1389–99. doi:10.1086/316886. PMID 11055895. 
  • Pineda M, Vilaseca MA, Artuch R, et al. (2000). “3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.”. Developmental medicine and child neurology 42 (9): 629–33. doi:10.1017/S0012162200001171. PMID 11034457. 
  • Baek JY, Jun DY, Taub D, Kim YH (2000). “Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization.”. Cytogenet. Cell Genet. 89 (1-2): 6–7. doi:10.1159/000015577. PMID 10894924. 
  • Cho HM, Jun DY, Bae MA, et al. (2000). “Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.”. Gene 245 (1): 193–201. doi:10.1016/S0378-1119(00)00009-3. PMID 10713460. 
  • Jaeken J, Detheux M, Van Maldergem L, et al. (1996). “3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.”. Arch. Dis. Child. 74 (6): 542–5. doi:10.1136/adc.74.6.542. PMID 8758134.