NDC1

NDC1
識別子
記号	NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
外部ID	OMIM: 610115 MGI: 1920037 HomoloGene: 41224 GeneCards: NDC1
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	53,838,463 bp
遺伝子の位置 (マウス)
染色体	4番染色体 (マウス)
終点	107,273,543 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• structural constituent of nuclear pore;
細胞の構成要素	• 細胞質; • integral component of membrane; • 核膜; • nuclear envelope; • 膜; • 細胞膜; • 核膜孔; • actin cytoskeleton; • 細胞核; • スピンドル極体; • nuclear pore transmembrane ring; • 宿主細胞;
生物学的プロセス	• mRNA transport; • nuclear pore complex assembly; • viral transcription; • protein sumoylation; • mitotic nuclear membrane disassembly; • homologous chromosome pairing at meiosis; • 精子形成; • タンパク質輸送; • regulation of cellular response to heat; • viral process; • mRNA export from nucleus; • intracellular transport of virus; • tRNA export from nucleus; • spindle pole body duplication; • regulation of gene silencing by miRNA; • regulation of glycolytic process; • 輸送; • nuclear pore organization;
	出典:Amigo / QuickGO
オルソログ
	55706
	72787
	ENSG00000058804
	ENSMUSG00000028614
	Q9BTX1
	Q8VCB1
	NM_001168551; NM_018087
	NM_028355
	NP_001162023; NP_060557
	NP_082631
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

ヌクレオポリンNDC1（英語: Nucleoporin NDC1）は、ヒトにおいてTMEM48 遺伝子にコードされているタンパク質である^[5]^[6]^[7]。核膜孔複合体にアラジン（英語版）を固定する^[8]。　

出典[編集]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000058804 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028614 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue”. Anat Rec A Discov Mol Cell Evol Biol 288 (7): 681–94. (Aug 2006). doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
^ “Nuclear membrane proteins with potential disease links found by subtractive proteomics”. Science 301 (5638): 1380–2. (Sep 2003). doi:10.1126/science.1088176. PMID 12958361.
^ “Entrez Gene: TMEM48 transmembrane protein 48”. 2019年7月23日閲覧。
^ Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). “The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope”. Biochemical and Biophysical Research Communications 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080.

“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
“Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. (2004). doi:10.1038/ng1285. PMID 14702039.
“The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
“Phosphoproteome analysis of the human mitotic spindle.”. Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. (2006). doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
“The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.”. Mol. Cell 22 (1): 93–103. (2006). doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
“NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes.”. J. Cell Biol. 173 (4): 509–19. (2006). doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
“The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. (2006). doi:10.1038/nature04727. PMID 16710414.
“Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”. Cell 127 (3): 635–48. (2006). doi:10.1016/j.cell.2006.09.026. PMID 17081983.