アンドロゲン受容体

AR
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3V49, 3V4A, 3ZQT, 4HLW, 3L3X, 3L3Z, 3RLJ, 3RLL, 4K7A, 4OEA, 4OED, 4OEY, 4OEZ, 4OFR, 4OFU, 4OGH, 4OH5, 4OH6, 4OHA, 4OIL, 4OIU, 4OJ9, 4OJB, 4OK1, 4OKB, 4OKT, 4OKW, 4OKX, 4OLM, 4QL8, 5CJ6
識別子
記号	AR, AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor
外部ID	OMIM: 313700 MGI: 88064 HomoloGene: 28 GeneCards: AR
遺伝子の位置 (ヒト)
染色体	X染色体
終点	67,730,619 bp
遺伝子の位置 (マウス)
染色体	X染色体 (マウス)
終点	97,366,821 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 金属イオン結合; • 脂質結合; • 受容体結合; • sequence-specific DNA binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein dimerization activity; • クロマチン結合; • zinc ion binding; • nuclear receptor activity; • ATPase binding; • androgen binding; • ステロイド結合; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 転写因子結合; • 血漿タンパク結合; • DNA結合; • beta-catenin binding; • POU domain binding; • 酵素結合; • DNA-binding transcription factor activity; • DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II general transcription initiation factor binding; • steroid hormone receptor activity;
細胞の構成要素	• 核質; • 細胞質; • 細胞質基質; • 細胞核; • 細胞膜; • nuclear speck; • 高分子複合体;
生物学的プロセス	• negative regulation of cell population proliferation; • positive regulation of cell differentiation; • positive regulation of NF-kappaB transcription factor activity; • sex differentiation; • シグナル伝達; • negative regulation of integrin biosynthetic process; • 細胞間シグナル伝達; • intracellular receptor signaling pathway; • 前立腺発生; • positive regulation of integrin biosynthetic process; • positive regulation of phosphorylation; • androgen receptor signaling pathway; • positive regulation of gene expression; • positive regulation of cell population proliferation; • positive regulation of transcription, DNA-templated; • negative regulation of extrinsic apoptotic signaling pathway; • transcription initiation from RNA polymerase II promoter; • regulation of transcription, DNA-templated; • 細胞増殖; • 細胞増殖; • positive regulation of transcription by RNA polymerase III; • protein complex oligomerization; • transcription, DNA-templated; • positive regulation of insulin-like growth factor receptor signaling pathway; • male somatic sex determination; • positive regulation of intracellular estrogen receptor signaling pathway; • negative regulation of epithelial cell proliferation; • 遺伝子発現調節; • regulation of systemic arterial blood pressure; • positive regulation of transcription by RNA polymerase II; • animal organ formation; • multicellular organism growth; • positive regulation of MAPK cascade; • in utero embryonic development; • 生殖器系発生; • tertiary branching involved in mammary gland duct morphogenesis; • 細胞のプロセス; • 男性生殖腺発生; • single fertilization; • 受精; • regulation of prostatic bud formation; • mammary gland alveolus development; • epithelial cell differentiation involved in prostate gland development; • epithelial cell morphogenesis; • regulation of transcription by RNA polymerase II; • seminiferous tubule development; • morphogenesis of an epithelial fold; • prostate gland epithelium morphogenesis; • Leydig cell differentiation; • reproductive structure development; • regulation of catalytic activity; • regulation of developmental growth; • lateral sprouting involved in mammary gland duct morphogenesis; • male genitalia morphogenesis; • prostate gland growth; • activation of prostate induction by androgen receptor signaling pathway; • 精子形成; • protein deubiquitination; • positive regulation of epithelial cell proliferation involved in prostate gland development; • negative regulation of transcription by RNA polymerase II; • cellular response to steroid hormone stimulus; • cellular response to testosterone stimulus; • regulation of protein localization to plasma membrane;
	出典:Amigo / QuickGO
オルソログ
	367
	11835
	ENSG00000169083
	ENSMUSG00000046532
	P10275,Q9NUA2
	P19091
	NM_001011645; NM_000044; NM_001348061; NM_001348063; NM_001348064
	NM_013476
NP_000035; NP_001011645; NP_001334990; NP_001334992; NP_001334993;
	NP_000035.2; NP_001011645.1
	NP_038504
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

アンドロゲン受容体 (AR)は核内受容体の一種。NR3C4 (nuclear receptor subfamily 3, group C, member 4)としても知られる。アンドロゲン受容体はアンドロゲンホルモンであるテストステロン、又は、ジヒドロテストステロンに細胞質で結合し活性化され、核内に移行する。アンドロゲン受容体はプロゲステロン受容体と構造が似ており、高用量のプロゲスチンはアンドロゲン受容体を阻害する。^[5]^[6]

アンドロゲン受容体は転写因子として働き遺伝子の発現を制御する。^[7]

画像[編集]

アンドロゲン受容体の機能: テストステロン(T)が細胞内に入り、5-α-還元酵素が存在すれば、dihydrotestosterone（DHT）に変換される。ステロイドと結合後、アンドロゲン受容体(AR)は構造変化しHS蛋白質(hsp)を分離する。ステロイド結合の前後どちらかにリン酸化(P)する。 AR は核に移行し、二量体化、DNA結合、補助活性化因子を採用する。標的の遺伝子は転写されタンパク質へと翻訳される。^[8]^[9]^[10]^[11]

参考文献[編集]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169083 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046532 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Progestins can mimic, inhibit and potentiate the actions of androgens”. Pharmacology & Therapeutics 23 (3): 443–59. (1983). doi:10.1016/0163-7258(83)90023-2. PMID 6371845.
^ “Progestogens with antiandrogenic properties”. Drugs 63 (5): 463–92. (2003). doi:10.2165/00003495-200363050-00003. PMID 12600226.
^ “Biological actions of androgens”. Endocrine Reviews 8 (1): 1–28. (February 1987). doi:10.1210/edrv-8-1-1. PMID 3549275.
^ “Androgen receptor defects: historical, clinical, and molecular perspectives”. Endocrine Reviews 16 (3): 271–321. (June 1995). doi:10.1210/edrv-16-3-271. PMID 7671849.
^ “Molecular pathology of the androgen receptor in male (in)fertility”. Reproductive Biomedicine Online 10 (1): 42–8. (January 2005). doi:10.1016/S1472-6483(10)60802-4. PMID 15705293.
^ “Trinucleotide repeats in the human androgen receptor: a molecular basis for disease”. Journal of Molecular Endocrinology 21 (3): 235–57. (December 1998). doi:10.1677/jme.0.0210235. PMID 9845666.
^ “Androgens and androgen receptor in prostate and ovarian malignancies”. Frontiers in Bioscience 8 (1-3): d780-800. (May 2003). doi:10.2741/1063. PMID 12700055.

画像[編集]

参考文献[編集]

関連項目[編集]