CD34

CD34
識別子
記号	CD34, entrez:947, CD34 molecule
外部ID	OMIM: 142230 MGI: 88329 HomoloGene: 1343 GeneCards: CD34
遺伝子の位置 (ヒト)
染色体	1番染色体 (ヒト)
終点	207,911,402 bp
遺伝子の位置 (マウス)
染色体	1番染色体 (マウス)
終点	194,643,587 bp
RNA発現パターン
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• 転写因子結合; • sulfate binding; • 炭水化物結合;
細胞の構成要素	• 細胞質; • integral component of membrane; • 膜; • 細胞膜; • integral component of plasma membrane; • 細胞外領域; • cell surface; • basal plasma membrane; • glomerular endothelium fenestra; • apical plasma membrane; • intercellular bridge; • perinuclear region of cytoplasm; • リソソーム; • external side of plasma membrane; • 細胞周辺;
生物学的プロセス	• extracellular exosome assembly; • stem cell proliferation; • positive regulation of interleukin-10 production; • cell motility; • negative regulation of blood coagulation; • metanephric glomerular mesangial cell differentiation; • 傍分泌シグナル伝達; • hematopoietic stem cell proliferation; • positive regulation of granulocyte colony-stimulating factor production; • 遺伝子発現の負の調節; • positive regulation of angiogenesis; • regulation of blood pressure; • vascular wound healing; • positive regulation of gene expression; • glomerular filtration; • negative regulation of nitric oxide biosynthetic process; • 細胞接着; • endothelial cell proliferation; • mesangial cell-matrix adhesion; • tissue homeostasis; • positive regulation of vasculogenesis; • endothelium development; • regulation of immune response; • negative regulation of cellular response to heat; • positive regulation of transforming growth factor beta production; • glomerular endothelium development; • negative regulation of tumor necrosis factor production; • cell-matrix adhesion; • 細胞増殖; • positive regulation of odontogenesis; • negative regulation of cellular response to hypoxia; • leukocyte migration; • シグナル伝達; • 分化転換; • negative regulation of neuron death; • cell-cell adhesion; • 造血;
	出典:Amigo / QuickGO
オルソログ
	947
	12490
	ENSG00000174059
	ENSMUSG00000016494
	P28906
	Q64314
	NM_001025109; NM_001773
	NM_001111059; NM_133654
	NP_001020280; NP_001764
	NP_001104529; NP_598415
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

CD34（cluster of differentiation 34）は、ヒト、マウス、ラットやその他の種においてCD34遺伝子にコードされる膜貫通型リン酸化糖タンパク質である^[5]^[6]^[7]。

CD34という名称は、細胞表面抗原を特定するCD分類に由来する。CD34はCivinらとTindleらによって独立に、造血幹細胞において細胞間接着因子として機能する細胞表面糖タンパク質として記載された^[8]^[9]^[10]^[11]。CD34は造血幹細胞を骨髄の細胞外マトリックスへ、もしくは直接的に間質細胞へ接着を媒介している可能性がある。臨床的には、CD34は骨髄移植のための造血幹細胞の選別や増幅と関係している。こうした組織学的・臨床的関連により、CD34の発現は造血幹細胞と関連付けられることが多いが、実際にはCD34は他の多くの細胞種にも存在している^[12]。

機能[編集]

CD34は1回膜貫通型シアロムチンタンパク質ファミリーの一員であり、初期の造血前駆細胞や血管関連前駆細胞で発現を示す^[13]。しかしながら、その正確な機能に関してはほとんど知られていない^[14]。

CD34はT細胞がリンパ節に進入するために必要な重要な接着分子である。CD34はリンパ節の内皮で発現しており、T細胞上のL-セレクチンが結合する^[15]^[16]。他の条件下では、CD34は「テフロン」のように作用して肥満細胞、好酸球、樹状細胞の前駆細胞の接着を防ぐ役割を果たしたり、血管内腔の開口を促進したりすることが示されている^[17]^[18]。また、CD34は好酸球や樹状細胞の前駆細胞のケモカイン依存的な遊走において、より選択的な役割を果たしている可能性も示唆されている^[19]^[20]。その作用機序がいかなるものであれ、あらゆる条件下でCD34やその類縁体であるポドカリキシン（英語版）、エンドグリカン（英語版）は細胞遊走を促進する作用を示す^[13]^[19]。

発現[編集]

さまざまな組織の非造血細胞において、CD34の存在は前駆細胞もしくは成体幹細胞表現型と関係している^[12]。

マウスやヒトで最も高い自己複製能を示す造血細胞である長期造血幹細胞（LT-HSC）は、分化系統が決定した細胞を除去した細胞集団（Lin⁻）におけるCD34陽性かつCD38陰性（CD34⁺CD38⁻）の細胞であることが示されている^[21]^[22]^[23]。その後の研究では、Lin⁻CD34⁺CD38⁻細胞集団内において、ローダミンの保持が少ない画分にLT-HSCが同定されることが報告されている^[24]^[25]^[26]。

一方マウスの造血幹細胞の中でCD34を発現しているものは約20%であり^[27]、その発現は可逆的に刺激される場合も抑制される場合もある^[28]。

臨床応用[編集]

CD34陽性細胞数測定は、造血幹細胞移植に用いられる造血幹細胞の数の定量のために臨床的に利用されることが多い。一般的にCD34は細胞量の有用なマーカーとなるが、一部の条件下ではCD34^＋定量が信頼性に欠けるものである可能性を示す証拠が得られている^[29]。CD34^＋細胞は血液試料から免疫磁気分離（英語版）によって単離され、移植片対宿主病の発生率の低いCD34陽性細胞移植に用いられる^[30]。

CD34^＋造血幹細胞の注入は、脊髄損傷、肝硬変、末梢血管疾患などさまざまな疾患の治療に臨床応用されている^[31]。

相互作用[編集]

CD34はCRKL（英語版）と相互作用することが示されている^[32]。

出典[編集]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Entrez Gene: CD34 CD34 molecule”. 2023年3月11日閲覧。
^ “Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells”. Journal of Immunology 148 (1): 267–271. (January 1992). PMID 1370171.
^ “Structure of the gene encoding CD34, a human hematopoietic stem cell antigen”. Genomics 12 (4): 788–794. (April 1992). doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
^ “Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells”. Journal of Immunology 133 (1): 157–165. (July 1984). PMID 6586833.
^ “A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow”. Leukemia Research 9 (1): 1–9. (1985). doi:10.1016/0145-2126(85)90016-5. PMID 3857402.
^ Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). “BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .”. In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.
^ Loken M. Shah V. Civin CI.. (1987). “Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence”. In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.
^ ^a ^b “Concise review: evidence for CD34 as a common marker for diverse progenitors”. Stem Cells 32 (6): 1380–1389. (June 2014). doi:10.1002/stem.1661. PMC 4260088. PMID 24497003.
^ ^a ^b “Novel functions of the CD34 family”. Journal of Cell Science 121 (Pt 22): 3683–3692. (November 2008). doi:10.1242/jcs.037507. PMID 18987355.
^ “Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis”. Immunologic Research 34 (1): 13–32. (2006). doi:10.1385/IR:34:1:13. PMID 16720896.
^ “Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules”. The American Journal of Pathology 152 (2): 469–477. (February 1998). PMC 1857953. PMID 9466573.
^ “Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis”. The American Journal of Gastroenterology 102 (7): 1499–1509. (July 2007). doi:10.1111/j.1572-0241.2007.01189.x. PMID 17459027.
^ “CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution”. Immunity 22 (1): 43–57. (January 2005). doi:10.1016/j.immuni.2004.11.014. PMID 15664158.
^ “The molecular basis of vascular lumen formation in the developing mouse aorta”. Developmental Cell 17 (4): 505–515. (October 2009). doi:10.1016/j.devcel.2009.08.011. PMID 19853564.
^ ^a ^b “CD34 facilitates the development of allergic asthma”. Blood 110 (6): 2005–2012. (September 2007). doi:10.1182/blood-2006-12-062448. PMID 17557898.
^ “CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis”. American Journal of Respiratory and Critical Care Medicine 184 (6): 687–698. (September 2011). doi:10.1164/rccm.201011-1764OC. PMC 3208601. PMID 21642249.
^ “Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells”. Blood 94 (12): 4093–4102. (December 1999). doi:10.1182/blood.V94.12.4093. PMID 10590054.
^ “Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice”. Proceedings of the National Academy of Sciences of the United States of America 99 (1): 413–418. (January 2002). Bibcode: 2002PNAS...99..413H. doi:10.1073/pnas.012336799. PMC 117574. PMID 11782553.
^ “Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3”. British Journal of Haematology 119 (2): 525–534. (November 2002). doi:10.1046/j.1365-2141.2002.03820.x. PMID 12406096.
^ “Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population”. Blood 109 (2): 543–545. (January 2007). doi:10.1182/blood-2006-06-030270. PMID 16990597.
^ “In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection”. Experimental Hematology 21 (5): 614–622. (May 1993). PMID 8513861.
^ “The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells”. Immunity 19 (4): 525–533. (October 2003). doi:10.1016/s1074-7613(03)00265-6. PMID 14563317.
^ “CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations”. Annals of the New York Academy of Sciences 938 (1): 139–145. (June 2001). Bibcode: 2001NYASA.938..139O. doi:10.1111/j.1749-6632.2001.tb03583.x. PMID 11458501.
^ “CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor”. Blood 96 (5): 1989–1993. (September 2000). doi:10.1182/blood.V96.5.1989. PMID 10961905.
^ “Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia”. Blood 134 (23): 2111–2115. (December 2019). doi:10.1182/blood.2019002301. PMC 7259822. PMID 31697810.
^ “Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34⁺ Selected and Unmodified Hematopoietic Stem Cell Transplantation”. Biology of Blood and Marrow Transplantation 24 (5): 1079–1087. (May 2018). doi:10.1016/j.bbmt.2018.01.001. PMC 6529210. PMID 29325829.
^ “Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience”. Cytotherapy 13 (8): 993–999. (September 2011). doi:10.3109/14653249.2011.579961. PMID 21671823.
^ “The adapter protein CrkL associates with CD34”. Blood 97 (12): 3768–3775. (June 2001). doi:10.1182/blood.V97.12.3768. PMID 11389015.

外部リンク[編集]

Antigens, CD34 - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
Mouse CD Antigen Chart
Human CD Antigen Chart
Human CD34 genome location and CD34 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[:1-5] “Entrez Gene: CD34 CD34 molecule”. 2023年3月11日閲覧。

[pmid1370171-6] “Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells”. Journal of Immunology 148 (1): 267–271. (January 1992). PMID 1370171.

[pmid1374051-7] “Structure of the gene encoding CD34, a human hematopoietic stem cell antigen”. Genomics 12 (4): 788–794. (April 1992). doi:10.1016/0888-7543(92)90310-O. PMID 1374051.

[:2-8] “Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells”. Journal of Immunology 133 (1): 157–165. (July 1984). PMID 6586833.

[:3-9] “A novel monoclonal antibody BI-3C5 recognises myeloblasts and non-B non-T lymphoblasts in acute leukaemias and CGL blast crises, and reacts with immature cells in normal bone marrow”. Leukemia Research 9 (1): 1–9. (1985). doi:10.1016/0145-2126(85)90016-5. PMID 3857402.

[:4-10] Tindle RW. Katz F. Martin H. Watt D. Catovsky D. Janossy G. Greaves M. (1987). “BI-3C5 (CD34) defines multipotential and lineage restricted progenitor cells and their leukaemic counterparts .”. In 'Leucocyte Typing 111: White Cell Differentiation Antigens. Oxford University Press, 654-655.

[:5-11] Loken M. Shah V. Civin CI.. (1987). “Characterization of myeloid antigens on human bone marrow using multicolour immunofluorescence”. In: McMichael, Leucocyte Typing III:White Cell Differentiation Antigens.Oxford University Press 630-635.

[:0-12] “Concise review: evidence for CD34 as a common marker for diverse progenitors”. Stem Cells 32 (6): 1380–1389. (June 2014). doi:10.1002/stem.1661. PMC 4260088. PMID 24497003.

[pmid18987355-13] “Novel functions of the CD34 family”. Journal of Cell Science 121 (Pt 22): 3683–3692. (November 2008). doi:10.1242/jcs.037507. PMID 18987355.

[pmid16720896-14] “Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis”. Immunologic Research 34 (1): 13–32. (2006). doi:10.1385/IR:34:1:13. PMID 16720896.

[pmid9466573-15] “Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules”. The American Journal of Pathology 152 (2): 469–477. (February 1998). PMC 1857953. PMID 9466573.

[pmid17459027-16] “Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis”. The American Journal of Gastroenterology 102 (7): 1499–1509. (July 2007). doi:10.1111/j.1572-0241.2007.01189.x. PMID 17459027.

[pmid15664158-17] “CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution”. Immunity 22 (1): 43–57. (January 2005). doi:10.1016/j.immuni.2004.11.014. PMID 15664158.

[pmid19853564-18] “The molecular basis of vascular lumen formation in the developing mouse aorta”. Developmental Cell 17 (4): 505–515. (October 2009). doi:10.1016/j.devcel.2009.08.011. PMID 19853564.

[pmid17557898-19] “CD34 facilitates the development of allergic asthma”. Blood 110 (6): 2005–2012. (September 2007). doi:10.1182/blood-2006-12-062448. PMID 17557898.

[pmid21642249-20] “CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis”. American Journal of Respiratory and Critical Care Medicine 184 (6): 687–698. (September 2011). doi:10.1164/rccm.201011-1764OC. PMC 3208601. PMID 21642249.

[Distinct_requirements_for_optimal_g-21] “Distinct requirements for optimal growth and In vitro expansion of human CD34(+)CD38(-) bone marrow long-term culture-initiating cells (LTC-IC), extended LTC-IC, and murine in vivo long-term reconstituting stem cells”. Blood 94 (12): 4093–4102. (December 1999). doi:10.1182/blood.V94.12.4093. PMID 10590054.

[:6-22] “Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice”. Proceedings of the National Academy of Sciences of the United States of America 99 (1): 413–418. (January 2002). Bibcode: 2002PNAS...99..413H. doi:10.1073/pnas.012336799. PMC 117574. PMID 11782553.

[:7-23] “Reconstitution of human haematopoiesis in non-obese diabetic/severe combined immunodeficient mice by clonal cells expanded from single CD34+CD38- cells expressing Flk2/Flt3”. British Journal of Haematology 119 (2): 525–534. (November 2002). doi:10.1046/j.1365-2141.2002.03820.x. PMID 12406096.

[:8-24] “Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population”. Blood 109 (2): 543–545. (January 2007). doi:10.1182/blood-2006-06-030270. PMID 16990597.

[:9-25] “In vivo and in vitro characterization of long-term repopulating primitive hematopoietic cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selection”. Experimental Hematology 21 (5): 614–622. (May 1993). PMID 8513861.

[:10-26] “The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells”. Immunity 19 (4): 525–533. (October 2003). doi:10.1016/s1074-7613(03)00265-6. PMID 14563317.

[:11-27] “CD34 expression by murine hematopoietic stem cells. Developmental changes and kinetic alterations”. Annals of the New York Academy of Sciences 938 (1): 139–145. (June 2001). Bibcode: 2001NYASA.938..139O. doi:10.1111/j.1749-6632.2001.tb03583.x. PMID 11458501.

[:12-28] “CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor”. Blood 96 (5): 1989–1993. (September 2000). doi:10.1182/blood.V96.5.1989. PMID 10961905.

[:13-29] “Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia”. Blood 134 (23): 2111–2115. (December 2019). doi:10.1182/blood.2019002301. PMC 7259822. PMID 31697810.

[:14-30] “Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34⁺ Selected and Unmodified Hematopoietic Stem Cell Transplantation”. Biology of Blood and Marrow Transplantation 24 (5): 1079–1087. (May 2018). doi:10.1016/j.bbmt.2018.01.001. PMC 6529210. PMID 29325829.

[pmid21671823-31] “Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience”. Cytotherapy 13 (8): 993–999. (September 2011). doi:10.3109/14653249.2011.579961. PMID 21671823.

[pmid11389015-32] “The adapter protein CrkL associates with CD34”. Blood 97 (12): 3768–3775. (June 2001). doi:10.1182/blood.V97.12.3768. PMID 11389015.

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表話編歴 CD分類
1-50	CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50
51-100	CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
101-150	CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150
151-200	CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
201-250	CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD240D · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249
251-300	CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299
301-350	CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350