preQ1シンターゼ

preQ1シンターゼ
識別子
EC番号	1.7.1.13
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索 PMC articles PubMed articles NCBI proteins

preQ₁シンターゼ（preQ₁ synthase）は、次の化学反応を触媒する酸化還元酵素である。

7-アミノメチル-7-カルバグアニン + 2 NADP⁺ $\rightleftharpoons$ 7-シアノ-7-カルバグアニン + 2 NADPH

反応式の通り、この酵素の基質は7-アミノメチル-7-カルバグアニンとNADP⁺、生成物は7-シアノ-7-カルバグアニンとNADPHである。

組織名は7-aminomethyl-7-carbaguanine:NADP⁺ oxidoreductaseで、別名にYkvM、QueF、preQ₀ reductase、preQ₀ oxidoreductase、7-cyano-7-deazaguanine reductase、7-aminomethyl-7-carbaguanine:NADP⁺ oxidoreductase、queuine synthase (incorrect as queuine is not the product)、queuine:NADP⁺ oxidoreductase (incorrect as queuine is not the product)がある。

参考文献

• Van Lanen, S.G., Reader, J.S., Swairjo, M.A., de Crécy-Lagard, V., Lee, B. and Iwata-Reuyl, D. (2005). “From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.”. Proc. Natl. Acad. Sci. USA 102: 4264-4269. PMID 15767583. 
• Yokoyama, S., Miyazawa, T., Iitaka, Y., Yamaizumi, Z., Kasai, H. and Nishimura, S. (1979). “Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA.”. Nature 282: 107-109. PMID 388227. 
• Kuchino, Y., Kasai, H., Nihei, K. and Nishimura, S. (1976). “Biosynthesis of the modified nucleoside Q in transfer RNA.”. Nucleic Acids Res. 3: 393-398. PMID 1257053. 
• Okada, N., Noguchi, S., Nishimura, S., Ohgi, T., Goto, T., Crain, P.F. and McCloskey, J.A. (1978). “Structure determination of a nucleoside Q precursor isolated from E. coli tRNA: 7-(aminomethyl)-7-deazaguanosine.”. Nucleic Acids Res. 5: 2289-2296. PMID 353740. 
• Noguchi, S., Yamaizumi, Z., Ohgi, T., Goto, T., Nishimura, Y., Hirota, Y. and Nishimura, S. (1978). “Isolation of Q nucleoside precursor present in tRNA of an E. coli mutant and its characterization as 7-(cyano)-7-deazaguanosine.”. Nucleic Acids Res. 5: 4215-4223. PMID 364423. 
• Swairjo, M.A., Reddy, R.R., Lee, B., Van Lanen, S.G., Brown, S., de Cr̩cy-Lagard, V., Iwata-Reuyl, D. and Schimmel, P. (2005). “Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.”. Acta Crystallogr. F Struct. Biol. Crystal. Co 61: 945-948.