3α(or20β)-ヒドロキシステロイドデヒドロゲナーゼ
| 3α(or20β)-ヒドロキシステロイドデヒドロゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| 識別子 | |||||||||
| EC番号 | 1.1.1.53 | ||||||||
| CAS登録番号 | 9028-42-6 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
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3α(or20β)-ヒドロキシステロイドデヒドロゲナーゼ（3-alpha(or 20-beta)-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。
- アンドロスタン-α,βジオール + NAD+ β-ヒドロキシアンドロスタン-3-オン + NADH + H+
反応式の通り、この酵素の基質はアンドロスタン-α,βジオールとNAD+、生成物はβ-ヒドロキシアンドロスタン-3-オンとNADHとH+である。
組織名は3α(or β)-hydroxysteroid:NAD+ oxidoreductaseで、別名にcortisone reductase, (R)-20-hydroxysteroid dehydrogenase, dehydrogenase, 20β-hydroxy steroid, Δ4-3-ketosteroid hydrogenase, 20β-hydroxysteroid dehydrogenase, 3α,20β-hydroxysteroid:NAD+-oxidoreductase, NADH-20β-hydroxysteroid dehydrogenase, 20β-HSDがある。
参考文献[編集]
- Edwards CA, Orr JC (1978). “Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans”. Biochemistry. 17: 4370–6. doi:10.1021/bi00614a003. PMID 718844.
- Kung CC, Huang WN, Huang YC, Yeh KC (2006). “Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry”. Proteomics. 6: 2746–58. doi:10.1002/pmic.200500108. PMID 16526091.
- Kung CC, Huang WN, Huang YC, Yeh KC (2006). “Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry”. Proteomics. 6: 2746–58. doi:10.1002/pmic.200500108. PMID 16526091.
- LYNN WS Jr, BROWN RH (1958). “The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015–30. PMID 13549484.
- Strickler RC, Covey DF, Tobias B (1980). “Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site”. Biochemistry. 19: 4950–4. doi:10.1021/bi00563a002. PMID 6936053.
- Sweet F, Samant BR (1980). “Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids”. Biochemistry. 19: 978–86. doi:10.1021/bi00546a023. PMID 6928375.