20α-ヒドロキシステロイドデヒドロゲナーゼ
| 20α-ヒドロキシステロイドデヒドロゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.1.1.149 | ||||||||
| CAS登録番号 | 9040-08-8 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
20α-ヒドロキシステロイドデヒドロゲナーゼ（20α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。
- 17α,20α-ジヒドロキシプレグン-4-エン-3-オン + NAD(P)+ 17α-ヒドロキシプロゲステロン + NAD(P)H + H+
反応式の通り、この酵素の基質は17α,20α-ジヒドロキシプレグン-4-エン-3-オンとNAD(P)+、生成物は17α-ヒドロキシプロゲステロンとNAD(P)HとH+である。
組織名は20α-hydroxysteroid:NAD(P)+ 20-oxidoreductaseで、別名に20α-hydroxy steroid dehydrogenase, 20α-HSD, 20α-HSDHがある。
参考文献[編集]
- Shikita M, Inano H, Tamaoki B (1967). “Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes”. Biochemistry. 6: 1760–4. doi:10.1021/bi00858a026. PMID 4382486.
- Strickler RC, Tobias B, Covey DF (1981). “Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site”. J. Biol. Chem. 256: 316–21. PMID 6935192.
- Wiest WG, Kidwell WR, Balogh K (April 1968). “Progesterone catabolism in the rat ovary: a regulatory mechanism for progestational potency during pregnancy”. Endocrinology 82 (4): 844–59. PMID 5742200.
- Wiest WG (December 1968). “On the function of 20 alpha-hydroxypregn-4-en-3-one during parturition in the rat”. Endocrinology 83 (6): 1181–4. PMID 5721991.
- Piekorz RP, Gingras S, Hoffmeyer A, Ihle JN, Weinstein Y (February 2005). “Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase”. Mol. Endocrinol. 19 (2): 431–40. doi:10.1210/me.2004-0302. PMID 15471942.
- Akinola LA, Poutanen M, Vihko R, Vihko P (July 1997). “Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats”. Endocrinology 138 (7): 2886–92. PMID 9202232.
- Weinstein Y (October 1977). “20alpha-hydroxysteroid dehydrogenase: a T lymphocyte-associated enzyme”. J. Immunol. 119 (4): 1223–9. PMID 302277.
- Weinstein Y, Lindner HR, Eckstein B (April 1977). “Thymus metabolises progesterone- possible enzymatic marker for T lymphocytes”. Nature 266 (5603): 632–3. PMID 300849.
- Ihle JN, Keller J, Oroszlan S, Henderson LE, Copeland TD, Fitch F, Prystowsky MB, Goldwasser E, Schrader JW, Palaszynski E, Dy M, Lebel B (July 1983). “Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity”. J. Immunol. 131 (1): 282–7. PMID 6190911.
- Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y (March 2007). “Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone”. Endocrinology 148 (3): 976–88. doi:10.1210/en.2006-1100. PMID 17122075.