ペプチド性メチオニン(R)-S-オキシドレダクターゼ

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ペプチド性メチオニン(R)-S-オキシドレダクターゼ
識別子
EC番号 1.8.4.12
データベース
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB構造 RCSB PDB PDBe PDBsum

ペプチド性メチオニン(R)-S-オキシドレダクターゼ(peptide-methionine (R)-S-oxide reductase)は、次の化学反応触媒する酸化還元酵素である。

ペプチド-L-メチオニン + チオレドキシンジスルフィド + H2O \rightleftharpoons ペプチド-L-メチオニン-(R)-S-オキシド + チオレドキシン

組織名はpeptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming]で、別名にMsrB; methionine sulfoxide reductase (ambiguous); pMSR; methionine S-oxide reductase (ambiguous); selenoprotein R; methionine S-oxide reductase (R-form oxidizing); methionine sulfoxide reductase B; SelR; SelX; PilB; pRMsrがある。

参考文献[編集]

  • Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). “Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.”. Biochem. Biophys. Res. Commun. 290: 62-65. PMID 11779133. 
  • Taylor, A.B., Benglis, D.M., Jr., Dhandayuthapani, S. and Hart, P.J. (2003). “Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.”. J. Bacteriol. 185: 4119-4126. PMID 12837786. 
  • Singh, V.K. and Moskovitz, J. (2003). “Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress.”. Microbiology 149: 2739-2747. PMID 14523107. 
  • Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231. 
  • Ezraty, B., Aussel, L. and Barras, F. (2005). “Methionine sulfoxide reductases in prokaryotes.”. Biochim. Biophys. Acta 1703: 221-229. PMID 15680230. 
  • Weissbach, H., Resnick, L. and Brot, N. (2005). “Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.”. Biochim. Biophys. Acta 1703: 203-212. PMID 15680228. 
  • Kauffmann, B., Aubry, A. and Favier, F. (2005). “The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions.”. Biochim. Biophys. Acta 1703: 249-260. PMID 15680233. 
  • Vougier, S., Mary, J. and Friguet, B. (2003). “Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells.”. Biochem. J. 373: 531-537. PMID 12693988. 
  • Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). “Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis.”. J. Biol. Chem. 277: 12016-12022. PMID 11812798. 
  • Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231. 
  • Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981). “Enzymatic reduction of protein-bound methionine sulfoxide.”. Proc. Natl. Acad. Sci. USA 78: 2155-2158. PMID 7017726.